Tuesday March 16, 2010

Q: Name at least 3 general conditions beside genetic increased plasma cholinesterase activity which may prolong succinylcholine action?


Answer:

1. Metoclopramide (Reglan) - which may prolong succinylcholine action due to effects on pseudocholinesterase.

2. Obesity - may cause resistance to succinylcholine due to more plasma cholinesterase activity.

3. In myasthenia gravis - due to reduced number of nicotinic, neuromuscular junctional receptors which is the target for the drug succinylcholine.